Can these work with bone loss?

It really depends upon how significant the bone loss is. This said, due to the adaptability of the material on the denture (i.e. like play-doh when warm / heated), you can sculp the denture, placing extra material in the areas where there may be more bone loss than other places. Of all dentures, you’ll most likely find the best success with Easy Denture due to its adaptability, but again it does come down to each person and how much bone loss there may be.